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Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo

✍ Scribed by Greenblatt, David J; Ehrenberg, Bruce L; Gunderman, John; Locniskar, Ann; Scavone, Joseph M; Harmatz, Jerold S; Shader, Richard I

Book ID
109844652
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
778 KB
Volume
45
Category
Article
ISSN
0009-9236

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Pharmacokinetics of midazolam in childre
Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration
✍ E. Rey; L. Delaunay; G. Pons; I. Murat; M. O. Richard; C. Saint-Maurice; G. Oliv πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 294 KB

Twelve children 1-5 y old were randomly assigned to receive midazolam 0.2 mg.kg-1 either by the intravenous (IV) or intranasal (IN) routes. After IN administration the rapid onset of absorption was observed (tmax 12 min). After both routes of administration the half-life was similar (2.2 h IN and 2.