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Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration

✍ Scribed by E. Rey; L. Delaunay; G. Pons; I. Murat; M. O. Richard; C. Saint-Maurice; G. Olive

Publisher: Springer
Year: 1991
Tongue: English
Weight: 294 KB
Volume: 41
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00314967

No coin nor oath required. For personal study only.

✦ Synopsis

Twelve children 1-5 y old were randomly assigned to receive midazolam 0.2 mg.kg-1 either by the intravenous (IV) or intranasal (IN) routes. After IN administration the rapid onset of absorption was observed (tmax 12 min). After both routes of administration the half-life was similar (2.2 h IN and 2.4 h IV). After IN administration the apparent plasma clearance and volume of distribution were about twice as high as after IV administration. The results are consistent with an estimated mean bioavailability of 55%.

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