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Pharmacogenetics of morphine: Potential implications in sickle cell disease

✍ Scribed by Deepika S. Darbari; Caterina P. Minniti; Sohail Rana; John van den Anker

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 91 KB
Volume: 83
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.21027

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✦ Synopsis

Abstract

Morphine is frequently used to treat painful episodes associated with sickle cell disease (SCD) but may fail to provide adequate analgesia in many patients. This concise review focuses on unique disease related changes in physiologic variables associated with SCD that impacts pharmacokinetics and pharmacodynamics of morphine and may contribute to the variability in analgesia. Emerging evidence suggests that the allelic variants in the genes involving the opioid (UGT2B7, OPRM1, and ABCB1 genes) and nonopioid system (COMT gene) can alter the efficacy of morphine. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.

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