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Pharmacogenetic determinants of azathioprine adverse effects in inflammatory bowel disease

✍ Scribed by Stocco Gabriele; Martelossi Stefano; Barabino Arrigo; Decorti Giuliana; Bartoli Fiora; Ventura Alessandro

Book ID: 119228308
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 65 KB
Volume: 38
Category: Article
ISSN: 1590-8658
DOI: 10.1016/j.dld.2006.07.027

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## Background: Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur in 15%-38% of patients and the majority are not explained by thiopurine-s-methyltransferase (tpmt) deficiency. azathioprine is known to induce glutathione depletion and consumption of glutathione is greate