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Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease

✍ Scribed by RICHARD B GEARRY; MURRAY L BARCLAY

Book ID: 108950289
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 106 KB
Volume: 20
Category: Article
ISSN: 0815-9319
DOI: 10.1111/j.1440-1746.2005.03832.x

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## Background: 6-mercaptopurine (6-mp) and its prodrug azathioprine (aza) are effective for the induction and maintenance of remission and reduction of corticosteroid exposure for pediatric inflammatory bowel disease (ibd). the standard dose of 6-mp is 1.0-1.5 mg/kg/day and for aza is 2.0-2.5 mg/kg