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W1197 Effectiveness and Adverse Effects of Azathioprine in Inflammatory Bowel Disease: 5-Year Follow-up Study

✍ Scribed by Bermejo, Fernando; Algaba, Alicia; Guerra, Ivan; Valer, Paz; Piqueras, Belén M.; García-Garzón, Silvia; Villa, José Carlos; Bermejo, Andrea; Agullo, José Luis Rodríguez

Book ID: 123166820
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 69 KB
Volume: 138
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(10)63091-0

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## Background: Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur in 15%-38% of patients and the majority are not explained by thiopurine-s-methyltransferase (tpmt) deficiency. azathioprine is known to induce glutathione depletion and consumption of glutathione is greate