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Phage-displayed Antibody Libraries of Synthetic Heavy Chain Complementarity Determining Regions

✍ Scribed by Sachdev S. Sidhu; Bing Li; Yvonne Chen; Frederic A. Fellouse; Charles Eigenbrot; Germaine Fuh

Book ID
116661249
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
853 KB
Volume
338
Category
Article
ISSN
0022-2836

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## Abstract The antigen binding site of an antibody is made up of residues residing in six hypervariable loops of the heavy and light chains. In most cases several or all of these loops are required for the establishment of the antigen‐binding surface. Five of these loops display a limited diversit