𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-Aβ Antibodies

✍ Scribed by Sehlin, Dag; Hedlund, Marie; Lord, Anna; Englund, Hillevi; Gellerfors, Pär; Paulie, Staffan; Lannfelt, Lars; Pettersson, Frida Ekholm

Book ID
120333336
Publisher
S. Karger AG
Year
2011
Tongue
English
Weight
174 KB
Volume
8
Category
Article
ISSN
1660-2854

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Length of the antibody heavy chain compl
Length of the antibody heavy chain complementarity determining region 3 as a specificity-determining factor
✍ Yvelise Barrios; Pernilla Jirholt; Mats Ohlin 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 110 KB

## Abstract The antigen binding site of an antibody is made up of residues residing in six hypervariable loops of the heavy and light chains. In most cases several or all of these loops are required for the establishment of the antigen‐binding surface. Five of these loops display a limited diversit

Succinimide formation at Asn 55 in the c
Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain
✍ Boxu Yan; Sean Steen; David Hambly; John Valliere-Douglass; Tim Vanden Bos; Scot 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB

We investigated the formation and stability of succinimide, an intermediate of deamidation events, in recombinant monoclonal antibodies (mAbs). During the course of an analytical development study of an IgG1 mAbs, we observed that a specific antibody population could be separated from the main produ