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Display of somatostatin-related peptides in the complementarity determining regions of an antibody light chain

✍ Scribed by Peter J. Simon; Kevin C. Brogle; Baiyang Wang; Donald J. Kyle; Daniel A. Soltis


Book ID
116177389
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
642 KB
Volume
440
Category
Article
ISSN
0003-9861

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We investigated the formation and stability of succinimide, an intermediate of deamidation events, in recombinant monoclonal antibodies (mAbs). During the course of an analytical development study of an IgG1 mAbs, we observed that a specific antibody population could be separated from the main produ