𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Ph-positive chronic myeloid leukemia with loss of the segment distal to M-bcr

✍ Scribed by Bent Pedersen; Claus R. Bartram; Johan Lanng Nielsen

Book ID
102220815
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
233 KB
Volume
4
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

We describe a patient with chronic myeloid leukemia (CML) and a 22q‐ but no 9q + chromosome. Southern blot analysis showed a BCR rearrangement. The patient soon developed profound and superficial thrombophlebitis in arms and legs and died from pulmonary embolisation 15 days after diagnosis. Five CML cases with a deletion of 22q but no known translocation of 22qll β†’ qter have been described earlier. The present patient is the first such case, however, in whom a BCR rearrangement has been demonstrated.

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