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Hypersensitivity of bcr-abl-positive progenitors to hyperthermia in patients with chronic myeloid leukemia

✍ Scribed by Thijsen, S F T; van Oostveen, J W; Schuurhuis, G J; Theijsmeijer, A P; Oudejans, C B M; van Wijk, I J; Langenhuijsen, M M A C; Ossenkoppele, G J


Book ID
110053640
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
272 KB
Volume
11
Category
Article
ISSN
0887-6924

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We have isolated the 3Ј BCR breakpoint junction of a complex BCR-ABL1 rearrangement found in leukemic cells with a cytogenetically normal karyotype, and the corresponding germline fragment that spanned the 3Ј BCR recombination site. Fluorescence in situ hybridization localized the 3Ј BCR recombinati