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pH-independent release of a weakly basic drug from water-insoluble and -soluble matrix tablets

โœ Scribed by A Streubel; J Siepmann; A Dashevsky; R Bodmeier


Book ID
114160636
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
273 KB
Volume
67
Category
Article
ISSN
0168-3659

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๐Ÿ“œ SIMILAR VOLUMES


Microenvironmental pH modulation based r
โœ Aditya S. Tatavarti; Stephen W. Hoag ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 240 KB

For weakly basic drugs, pH-dependent solubility characteristics can translate into low and incomplete release of these drugs from sustained release formulations. The objective of this study was to quantitatively analyze the relationship between microenvironmental pH modulation and release enhancemen