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Programmable drug release of highly water-soluble pentoxifylline from dry-coated wax matrix tablets

โœ Scribed by Makoto Otsuka; Yoshihisa Matsuda


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
562 KB
Volume
84
Category
Article
ISSN
0022-3549

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Sustained-release formulations such as hydroxypropyl methylcellulose (HPMC)based hydrophilic matrix tablets of poorly water-soluble drugs often result in incomplete release because of the poor solubility and dissolution rate of the drug in the hydrophilic matrix. Sulfobutylether-b-cyclodextrins ((SB