PET studies of [18F]methyl-MK-801, a potential NMDA receptor complex radioligand
โ Scribed by Blin, J.; Denis, A.; Yamaguchi, T.; Crouzel, C.; MacKenzie, E.T.; Baron, J.C.
- Book ID
- 122650179
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 340 KB
- Volume
- 121
- Category
- Article
- ISSN
- 0304-3940
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The purpose of this study was to develop a radiopharmaceutical that could be used to selectively image 5-HT 1A receptors with positron emission tomography (PET). No-carrier-added 4-(28-methoxyphenyl)-1-[28-(N-29-pyridinyl)-p-[ 18 F]fluorobenzamido]ethylpiperazine ( p-[ 18 F]-MPPF, 2) was synthesized
## Abstract In an attempt to visualize the NMDA glutamatergic receptors and after checking the biological activity of the cold 3โfluoromethylโTCP 3, 3โ[^18^F]โfluoroโmethylโTCP 4 was synthesized by a nucleophilic substitution of 3โbromomethylโTCP 5 with [^18^F^โ^].
## Abstract This study evaluated the utility of __(S)โN__โ[(1โethylโ2โpyrrolidinyl)methyl]โ5โ(3โ[^18^F]fluoropropyl)โ2,3โdimethoxybenzamide ([^18^F]fluoropropylepidepride), [^18^F]5โFPrEpid, as a ligar d for PET studies of cerebral dopamine D2 receptors. The in vitro affinity for the rat striatal d