## Abstract This study evaluated the utility of __(S)โN__โ[(1โethylโ2โpyrrolidinyl)methyl]โ5โ(3โ[^18^F]fluoropropyl)โ2,3โdimethoxybenzamide ([^18^F]fluoropropylepidepride), [^18^F]5โFPrEpid, as a ligar d for PET studies of cerebral dopamine D2 receptors. The in vitro affinity for the rat striatal d
Preparation of [18F]Flumazenil, a Potential Radioligand for PET Imaging of Central Benzodiazepine Receptors, by Isotope Exchange
โ Scribed by N. N. Ryzhikov; N. A. Gomzina; O. S. Fedorova; D. A. Vasil'ev; A. P. Kostikov; R. N. Krasikova
- Book ID
- 111605906
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 62 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1066-3622
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## Abstract In this study, we synthesized and evaluated a new spirocyclic piperidine derivative 3, containing a 4โfluorobutyl side chain, as a PET radioligand for neuroimaging of ฯ~1~ receptors. Inโ vitro, compound 3 displayed high affinity for ฯ~1~ receptors (__K__~i~=1.2โ nM) as well as high select