Persistent infection by human parvovirus B19 in qualified blood donors
β Scribed by Harumichi Matsukura; Sachiko Shibata; Yoshihiko Tani; Hirotoshi Shibata; Rika A. Furuta
- Book ID
- 109144081
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 277 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0372-1248
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Background and Procedure. The frequency and clinical importance of parvovirus B19 infection were studied in children investigated or treated for various malignancies and cytopenias. Results. B19 infection was thus demonstrated in six out of 53 unselected children with malignancies by bone marrow exa
## Abstract A subset of parvovirus B19 (B19) infected patients retains the infection for years, as defined by detection of B19 DNA in bone marrow. Thus far, analysis of B19βspecific humoral immune responses and viral genome variations has not revealed a mechanism for the absent viral clearance. In
## Abstract B19 infection can be acquired by transmission with blood factors in patients with congenital bleeding disorders, requiring clotting factor concentrates. In immunodeficient patients, the failure of immunity to clear B19 virus may produce persistent infections. The presence of B19 DNA in