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Aberrant cellular immune responses in humans infected persistently with parvovirus B19

✍ Scribed by Adiba Isa; Oscar Norbeck; Taha Hirbod; Anders Lundqvist; Victoria Kasprowicz; Paul Bowness; Paul Klenerman; Kristina Broliden; Thomas Tolfvenstam

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
99 KB
Volume
78
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

A subset of parvovirus B19 (B19) infected patients retains the infection for years, as defined by detection of B19 DNA in bone marrow. Thus far, analysis of B19‐specific humoral immune responses and viral genome variations has not revealed a mechanism for the absent viral clearance. In this study, ex‐vivo cellular immune responses were assessed by enzyme linked immunospot assay mounted against the majority of the translated viral genome. Compared to seropositive healthy individuals, individuals with B19 persistence (2–8 years) showed larger number of responses to the structural proteins (P = 0.0022), whereas responses to the non‐structural protein were of lower magnitude (P = 0.012). These observations provide the first findings of immunological discrepancies between individuals with B19 persistence and healthy individuals, findings that may reflect both failed immunity and antigenic exhaustion. J. Med. Virol. 78:129–133, 2006. © 2005 Wiley‐Liss, inc.

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