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Persistent expansion of CD4+ effector memory T cells in Wegener's granulomatosis

✍ Scribed by Abdulahad, W H; van der Geld, Y M; Stegeman, C A; Kallenberg, C G M

Book ID: 110053004
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 317 KB
Volume: 70
Category: Article
ISSN: 0085-2538
DOI: 10.1038/sj.ki.5001670

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## Abstract ## Objective Accumulating data support the role of regulatory T cells, a subset of CD4+ T cells that expresses CD25^high^ and the transcription factor forkhead box P3 (FoxP3), in controlling and preventing autoimmunity. In Wegener's granulomatosis (WG), an autoimmune vasculitis, up‐reg