Persistent corticotropin-releasing factor1 receptor desensitization and downregulation in the human neuroblastoma cell line IMR-32
โ Scribed by Patrick H. Roseboom; Colleen M. Urben; Ned H. Kalin
- Book ID
- 117385721
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 955 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0169-328X
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The gamma-aminobutyric acid (GABA) response profiles of IMR-32 human neuroblastoma cells were examined using whole-cell patch clamp and RT-PCR techniques. GABA activated a concentration-dependent and bicuculline-sensitive current, and RT-PCR revealed the expression of multiple GABA(A) receptor subun
## Abstract The nerve growth factor protein (NGF) stimulates neurite outgrowth from embryonic sensory ganglia and sympathetic ganglia at all stages of development. In addition, NGF is required for the maintenance of the differentiated state in adult sympathetic ganglia. A clonal cell line, IMRโ32,