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Peroxynitrite donor impairs excitability of hippocampal CA1 neurons by inhibiting voltage-gated potassium currents

✍ Scribed by Zhao Wei Liu; Ting Lei; Tao Zhang; Zhuo Yang


Book ID
119379769
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
508 KB
Volume
175
Category
Article
ISSN
0378-4274

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## ABSTRACT The aim of this study was to investigate the effects of nano‐CuO on voltage‐gated sodium current (__I__~Na~) in hippocampal CA1 neurons. The results suggested that nano‐CuO inhibited amplitudes of __I__~Na~ currents and prolonged peak rise time of action potential (AP). The responses to