Nano-CuO inhibited voltage-gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G-proteins pathway
✍ Scribed by Zhaowei Liu; Shichang Liu; Guogang Ren; Tao Zhang; Zhuo Yang
- Book ID
- 102871150
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 835 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0260-437X
- DOI
- 10.1002/jat.1611
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✦ Synopsis
ABSTRACT
The aim of this study was to investigate the effects of nano‐CuO on voltage‐gated sodium current (I~Na~) in hippocampal CA1 neurons. The results suggested that nano‐CuO inhibited amplitudes of I~Na~ currents and prolonged peak rise time of action potential (AP). The responses to nano‐CuO were inhibited by reactive oxygen species (ROS) scavenger. However, the G‐proteins inhibitor did not block the effects of nano‐CuO. The effects of nano‐CuO were mediated through activation of ROS‐I~Na~‐AP signaling cascades and independent from G‐proteins pathway. Copyright © 2011 John Wiley & Sons, Ltd.