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Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the β4 integrin and the PI3k pathway

✍ Scribed by Baril, P; Gangeswaran, R; Mahon, P C; Caulee, K; Kocher, H M; Harada, T; Zhu, M; Kalthoff, H; Crnogorac-Jurcevic, T; Lemoine, N R

Book ID: 110072015
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 626 KB
Volume: 26
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1210009

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## Abstract The hypoxic environment in tumor is reported to play an important role in pancreatic cancer progression. The interaction between stromal and cancer cells also contributes to the malignant behavior of pancreatic cancer. In the present study, we investigated whether hypoxic stimulation af