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Periodate Oxidation of Sulfides to Sulfoxides. Scope of the Reaction

✍ Scribed by Leonard, Nelson J.; Johnson, Carl R.


Book ID
125464832
Publisher
American Chemical Society
Year
1962
Tongue
English
Weight
332 KB
Volume
27
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES


An efficient asymmetric oxidation of sul
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The Sharpless reagent (Ti(OiPr)4 t 1 mol eq. diethyl tartrate (DET) t 2 J-BuOOH) modified by addition of one mol eq. H20 gives a new homogeneous reagent which cleanly oxidizes sulfidesinto sulfoxides in dichloromethane. The best results were obtained for the stoichiometry Ti/DET/ H20/J-BuOOH = 1:2:1

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A variety of symmetrical and unsymmetrical sulfides have been selectively and expeditiously oxidized to either sulfoxides or salfones in good yields using wet silica-supported sodium periodate under microwave thermolysis conditions.