The purpose of this paper is to show that the sensitivity and specificity estimates obtained by 'discrepant analysis' are biased. Discrepant analysis is a widely used technique that attempts to provide estimates of sensitivity and specificity in the presence of an imperfect gold standard. Many resea
Perinatal transmission of chlamydia trachomatis. The use of serological tests in detecting infected women
โ Scribed by Lise Dannevig; B. Schive; B. K. Straume; K. Melby
- Publisher
- Springer-Verlag
- Year
- 1991
- Tongue
- English
- Weight
- 391 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0300-8126
No coin nor oath required. For personal study only.
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## Objective: To compare the reliability of ligase chain reaction (lcr) to polymerase chain reaction (pcr) in detecting chlamydia trachomatis endocervical infections. ## Methods: We conducted a prospective study of 486 patients at risk for chlamydial infection of the endocervix. we obtained two e
Hadgu raises concerns about how diagnostic tests for detecting Chlamydia trachomatis are evaluated and states that 'discrepant analysis strongly biases evaluations in favour of the new test'. He questions the sensitivity and specificity figures that are generated by discrepant analysis. It may be us