Percutaneous absorption of 4,4′-methylene-bis(2-chloroaniline) and 4,4′-methylenedianiline through rat and human skin in vitro
✍ Scribed by Hotchkiss, S.A.M.; Hewitt, P.; Caldwell, J.
- Book ID
- 123210432
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 691 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0887-2333
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## Abstract 4,4′‐Methylene‐bis(2‐chloroaniline) (MBOCA), a known carcinogen in several animal species, is frequently found in the urine of humans exposed to the compound in the plastics industry. A knowledge of the metabolism and tissue distribution of MBOCA would be of value in monitoring exposure
A sensitive and specific gas chromatographic/mass spectrometric assay is described for the determination of Nacetyl 4,4'-methylene dianiline (N-acetyl MDA) and N-acetyl 4,4'-methylene-bis(2-chloroaniline) (N-acetyl MbOCA) in urine. The method is based on the solvent extraction of the compounds toget