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Determination of the N-acetyl metabolites of 4,4′-methylene dianiline and 4,4′-methylene-bis(2-chloroaniline) in urine

✍ Scribed by John Cocker; Alan R. Boobis; Donald S. Davies

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 569 KB
Volume: 17
Category: Article
ISSN: 1076-5174
DOI: 10.1002/bms.1200170303

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✦ Synopsis

A sensitive and specific gas chromatographic/mass spectrometric assay is described for the determination of Nacetyl 4,4'-methylene dianiline (N-acetyl MDA) and N-acetyl 4,4'-methylene-bis(2-chloroaniline) (N-acetyl MbOCA) in urine. The method is based on the solvent extraction of the compounds together with deuteriumlabelled internal standards, the compounds being separated and detected by capillary gas chromatography/mass spectrometry as their pentafluoropropyl derivatives. The method has been applied to the detection of N-acetyl MbOCA and N-acetyl MDA in the urine of workers occupationally exposed to MbOCA and MDA. The results show that whilst N-acetyl MbOCA is a relatively minor urinary metabolite a significant proportion of MDA is excreted as the N-acetylated compound.

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