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Peracid oxidation of trimethylsilyl enol ethers: A facile α-hydroxylation procedure

✍ Scribed by G.M. Rubottom; M.A. Vazquez; D.R. Pelegrina

Publisher
Elsevier Science
Year
1974
Tongue
French
Weight
192 KB
Volume
15
Category
Article
ISSN
0040-4039

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✦ Synopsis

The oxidation of trimethylsilyl enol ethers, L, in hexane solution, with s-chloroperbenzoic acid (MCPBA), followed by treatment of the crude reaction mixture with acid or base, affords a general, high yield method for the specific a-hydroxylation of ketones (ie, acyloin, 2, production)(Equation l)!

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