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Double hydroxylation of enol silyl ethers. A single-step synthesis of α, α′-dihydroxy ketones

✍ Scribed by Yoshiaki Horiguchi; Eiichi Nakamura; Isao Kuwajima

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
237 KB
Volume
30
Category
Article
ISSN
0040-4039

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α-Hydroxylation of ketones: Osmium tetroxide/N-methylmorpholine-N-oxide oxidation of silyl enol ethers
✍ J.P. McCormick; Witold Tomasik; Mark W. Johnson 📂 Article 📅 1981 🏛 Elsevier Science 🌐 French ⚖ 244 KB

Osmium tetroxide/N-methylmorpholine-N-oxide oxidation of silyl enol ethers, derived from ketones with either kinetic or thermodynamic regiochemical control, produces a-ketols in good to excellent yields. The search for means to introduce hydroxyl functionality adjacent to carbonyl has led to develo