𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Peptides from non-amino acid sources III. Synthesis of diketopiperazine derivatives from ketene acetal.

✍ Scribed by G.J. Koves; I.G. Csizmadia

Book ID
104247856
Publisher
Elsevier Science
Year
1971
Tongue
French
Weight
192 KB
Volume
12
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

We wish to report a new synthetic route to N,N'-disuhstituted diketopiperazines (VI) via their tetraethyl acetals (V) from ketene acetal (I) and sulfonic azides (II). Compounds I and II reacted completely within 24 hours at -20Β°C in a 1:l molar ratio in the absence of a solvent.

The yield was nearly quantitative with a small amount of ether soluble oily byproduct.

πŸ“œ SIMILAR VOLUMES

Synthesis of thiazole amino-acids derive
Synthesis of thiazole amino-acids derived from natural peptides
✍ G.W. Kenner; R.C. Sheppard; C.E. Stehr πŸ“‚ Article πŸ“… 1960 πŸ› Elsevier Science 🌐 French βš– 136 KB

IN connexion with our studies on the antibiotic, Thiostrepton,' we have prepared a number of 2-(a-aminoalkyl)-thiazole-4-carboxylic acids (I, R=H, Me, Et end CHMe2). Since thiazole structures have been advanced for degradation products of other peptide antibiotics, 2,j a brief account of our results

Synthesis of non-proteinogenic amino aci
Synthesis of non-proteinogenic amino acids from N-(4-toluenesulfonyl)dehydroamino acid derivatives
✍ Paula M.T. Ferreira; HernΓ’ni L.S. Maia; Luı́s S. Monteiro πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 174 KB

By treating N-(4-toluenesulfonyl)-N-(tert-butyloxycarbonyl)-dehydroamino acid derivatives with different reactants under different conditions, a variety of new amino acids are obtained, viz. (i) a-alcoxy-a-amino acids, (ii) a,a-diamino acids and (iii) novel b-substituted dehydroamino acids.