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Synthesis of thiazole amino-acids derived from natural peptides

✍ Scribed by G.W. Kenner; R.C. Sheppard; C.E. Stehr

Publisher
Elsevier Science
Year
1960
Tongue
French
Weight
136 KB
Volume
1
Category
Article
ISSN
0040-4039

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✦ Synopsis

IN connexion with our studies on the antibiotic, Thiostrepton,' we have prepared a number of 2-(a-aminoalkyl)-thiazole-4-carboxylic acids (I, R=H, Me, Et end CHMe2). Since thiazole structures have been advanced for degradation products of other peptide antibiotics, 2,j a brief account of our results is given here.

I II

The thiazole amino-acids (I) were obtained by reaction of the '

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Peptide Dendrimers from Natural Amino Ac
Peptide Dendrimers from Natural Amino Acids
✍ Yoonkyung Kim; Fanwen Zeng; Steven C. Zimmerman πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 175 KB πŸ‘ 1 views

The high-yielding cyanoethylation Β± hydrogenation strategy was used to prepare simple AB 2 monomers from natural amino acids. Third-generation peptide dendrimers were assembled from these monomers on a polyethylene glycol (PEG) resin by standard Boc peptide coupling methods. Preliminary conformation