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Peptide Dendrimers from Natural Amino Acids

✍ Scribed by Yoonkyung Kim; Fanwen Zeng; Steven C. Zimmerman

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 175 KB
Volume: 5
Category: Article
ISSN: 0947-6539
DOI: 10.1002/(sici)1521-3765(19990702)5:7<2133::aid-chem2133>3.0.co;2-j

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✦ Synopsis

The high-yielding cyanoethylation ± hydrogenation strategy was used to prepare simple AB 2 monomers from natural amino acids. Third-generation peptide dendrimers were assembled from these monomers on a polyethylene glycol (PEG) resin by standard Boc peptide coupling methods. Preliminary conformational studies were conducted on these chiral peptide dendrimers by size-exclusion chromatography, optical activity measurements, and investigation of the solid-state properties. These peptide dendrimers have potential applications as drug-delivery agents, asymmetric catalysts, peptido-and protein mimetics, and new biomaterials.

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