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Peptide Interaction with a Class I Major Histocompatibility Complex-Encoded Molecule: Allosteric Control of the Ternary Complex Stability †

✍ Scribed by Gakamsky, Dmitry M.; Bjorkman, Pamela J.; Pecht, Israel


Book ID
127387508
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
739 KB
Volume
35
Category
Article
ISSN
0006-2960

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A direct and sensitive biochemical assay to measure the interaction in solution between peptides and affinity-purified major histocompatibility complex (MHC) class I molecules has been generated. Specific binding reflecting the known class I restriction of cytotoxicT cell responses was obtained. Add