## Abstract The activation of helper T cells by peptides bound to proteins of the class II Major Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The primary functional requirement imposed on MHC II proteins is the ability to efficiently bind thousands of diff
The binding affinity and dissociation rates of peptides for class I major histocompatibility complex molecules
β Scribed by Vincenzo Cerundolo; Timothy Elliott; John Elvin; Judy Bastin; Hans-Georg Rammensee; Alain Townsend
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 778 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
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## Abstract At the surface of the murine T lymphoma cell line RMAβS, the expression of βemptyβ class I molecules can be dramatically enhanced by culture at 26Β°C. These class I molecules are unstable following transfer to 37Β°C unless they are loaded with exogenously added peptides. Class I heterodim