A fungal metabolite which inhibits the interaction of CD4 with major histocompatibility complex-encoded class II molecules
β Scribed by Guy Gammon; Glenda Chandler; Paul Depledge; Catherine Elcock; Stephen Wrigley; John Moore; Giancarlo Cammarota; Francesco Sinigaglia; Michael Moore
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 823 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0014-2980
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## Down-regulation of class I1 major histocompatibility complex molecules on antigen presenting cells after interaction with helper T cells The recognition of antigenic peptides by CD4+ helper Tcells is demonstrated here to result in a dramatic (up to 90%) decrease in expression of major histocomp