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Peptide Coupling of Unprotected Amino Acids Through in situ p-Nitrophenyl Ester Formation.

✍ Scribed by Paul Gagnon; Xicai Huang; Eric Therrien; Jeffrey W. Keillor

Publisher
John Wiley and Sons
Year
2003
Weight
101 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

For Abstract see ChemInform Abstract in Full Text.

πŸ“œ SIMILAR VOLUMES

Peptide coupling of unprotected amino ac
Peptide coupling of unprotected amino acids through in situ p-nitrophenyl ester formation
✍ Paul Gagnon; Xicai Huang; Eric Therrien; Jeffrey W. Keillor πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 80 KB

Several series of dipeptides and tripeptides were prepared via an activation-coupling method involving the in situ formation of a p-nitrophenyl ester of an (N-protected) amino acid, followed by coupling with an unprotected amino acid in partially aqueous solutions. The resulting peptide is easily is

Deprotection of N-Alloc amines by Pd(0)/
Deprotection of N-Alloc amines by Pd(0)/DABCOβ€”an efficient method for in situ peptide coupling of labile amino acids
✍ Chiara Zorn; Frieder Gnad; Sunnhild Salmen; Timothy Herpin; Oliver Reiser πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 117 KB

A highly efficient one-pot deprotection/peptide coupling protocol of N-Alloc amino acids with activated N-Boc or N-Fmoc amino acids was developed in solution and on solid phase. DABCO was found to be especially effective for the deprotection of the N-Alloc group, resulting in short reaction times (1