Deprotection of N-Alloc amines by Pd(0)/DABCO—an efficient method for in situ peptide coupling of labile amino acids

✍ Scribed by Chiara Zorn; Frieder Gnad; Sunnhild Salmen; Timothy Herpin; Oliver Reiser

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 117 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01453-8

✦ Synopsis

A highly efficient one-pot deprotection/peptide coupling protocol of N-Alloc amino acids with activated N-Boc or N-Fmoc amino acids was developed in solution and on solid phase. DABCO was found to be especially effective for the deprotection of the N-Alloc group, resulting in short reaction times (10-20 min) and allowing the coupling of amino acids that are unstable in unprotected forms.