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ChemInform Abstract: Deprotection of N-Alloc Amines by Pd(0)/DABCO — An Efficient Method for in situ Peptide Coupling of Labile Amino Acids.

✍ Scribed by Chiara Zorn; Frieder Gnad; Sunnhild Salmen; Timothy Herpin; Oliver Reiser

Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 33
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200202206

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Abstract

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Deprotection of N-Alloc amines by Pd(0)/

Deprotection of N-Alloc amines by Pd(0)/DABCO—an efficient method for in situ peptide coupling of labile amino acids

✍ Chiara Zorn; Frieder Gnad; Sunnhild Salmen; Timothy Herpin; Oliver Reiser 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 117 KB

A highly efficient one-pot deprotection/peptide coupling protocol of N-Alloc amino acids with activated N-Boc or N-Fmoc amino acids was developed in solution and on solid phase. DABCO was found to be especially effective for the deprotection of the N-Alloc group, resulting in short reaction times (1