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Orthogonal coupling of unprotected peptide segments through histidyl amino terminus

โœ Scribed by Lianshan Zhang; James P Tam


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
201 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


We report a new scheme for orthogonal coupling of unprotected peptide segments through the anchimeric assistance of a proximally located histidine at the amino terminus.


๐Ÿ“œ SIMILAR VOLUMES


Peptide coupling of unprotected amino ac
โœ Paul Gagnon; Xicai Huang; Eric Therrien; Jeffrey W. Keillor ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 80 KB

Several series of dipeptides and tripeptides were prepared via an activation-coupling method involving the in situ formation of a p-nitrophenyl ester of an (N-protected) amino acid, followed by coupling with an unprotected amino acid in partially aqueous solutions. The resulting peptide is easily is