✦ LIBER ✦

Penicillinase inactivates kanamycin in the presence of carbenicillin

✍ Scribed by F. Dums; W. Klingmüller

Publisher: Springer
Year: 1985
Tongue: English
Weight: 237 KB
Volume: 72
Category: Article
ISSN: 0028-1042
DOI: 10.1007/bf00410602

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✦ Synopsis

esters [11] and the daphnane orthoester mezerein [12] have become important tools in cancer research at the cellular level and in mechanistic studies. The potentiation of 3PS activity of daphnane orthoesters by 2 could provide further insight into the mode of action of the antitumour activity of this type of compound. The effect appears to be dependent on the specific structure of 2, in particular the presence of three unconjugated double bonds in the fatty acid moiety which can be easily peroxidized [13].

We thank David Bull Laboratories for financial support and M. Barley, S. Berry, A. Blofeld, A. Brown, A. Gooley, A. Tseng and K. Whitehurst for special assistance.

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