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Pediatric Phase I Trial and Pharmacokinetic Study of Dasatinib: A Report From the Children's Oncology Group Phase I Consortium

โœ Scribed by Aplenc, R.; Blaney, S. M.; Strauss, L. C.; Balis, F. M.; Shusterman, S.; Ingle, A. M.; Agrawal, S.; Sun, J.; Wright, J. J.; Adamson, P. C.


Book ID
111676044
Publisher
American Society of Clinical Oncology
Year
2011
Tongue
English
Weight
180 KB
Volume
29
Category
Article
ISSN
0732-183X

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## Abstract Trimetrexate (TMTX), a lipophilic antifol, was evaluated in a Pediatric Oncology Group (POG) Phase I trial in children with refractory solid tumors. TMTX was administered intravenously daily ร— 5 every three weeks. Starting dose was 6.4 mg/m^2^/day. Dose was escalated by 20% until the ma