## Abstract Trimetrexate (TMTX), a lipophilic antifol, was evaluated in a Pediatric Oncology Group (POG) Phase I trial in children with refractory solid tumors. TMTX was administered intravenously daily Γ 5 every three weeks. Starting dose was 6.4 mg/m^2^/day. Dose was escalated by 20% until the ma
Phase I trial of indicine-N-oxide in children with leukemia and solid tumors: a Pediatric Oncology Group study
β Scribed by V. Michael Whitehead; Mark L. Bernstein; Roger Vega; Tribhawan Vats; Paul Dyment; Teresa J. Vietti; Jeffrey Krischer
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 296 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
We used indicine N-oxide to treat 46 children with malignant solid tumors: 17 with osteosarcoma, 12 with neuroblastoma, 13 with a brain tumor, and 4 with other miscellaneous tumors. The efficacy and toxicity of the drug was assessed at the dose of 2000 mg/m2/day for five consecutive days. None of th
## Abstract To determine the maximum tolerated dose of 5βfluorouracil administered as a 120βhour continuous intravenous infusion to pediatric patients, we performed a phase I study using a starting dosage of 900 mg/m^2^/day. The maximum tolerated dosage (MTD) was 1,100 mg/m^2^/day. At this dosage l
## Abstract Eleven patients with osteogenic sarcoma (9), Hodgkin disease (1), and mesenchymal sarcoma (1), were treated with 5βfluorouracil (5βFU) and cisplatin (DDP). Myelosuppression and vomiting of variable degrees occurred in all. No responses were seen.