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Peak homogeneity determination for the validation of high-performance liquid chromatographic assay methods

โœ Scribed by G. T. Carter; R. E. Schiesswohl; H. Burke; R. Yang


Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
499 KB
Volume
71
Category
Article
ISSN
0022-3549

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High performance liquid chromatographic
โœ Besenfelder, E. ;Endele, R. ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 215 KB ๐Ÿ‘ 2 views

Spironolactone (I), a potassium sparing diuretic, is widely used in the treatment of edema. Metabolic degradation starts with rapid deacetylation, leading to the short lived a-thiol [l]. Subsequent elimination of hydrogen sulfide yields canrenone (II), which exists in enzymatic equilibrium with canr