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High performance liquid chromatographic method for the determination of nimesulide and its impurities

โœ Scribed by Nonzioli, A. ;Luque, G. ;Fernandez, C.

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
303 KB
Volume
12
Category
Article
ISSN
0935-6304

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High performance liquid chromatographic
High performance liquid chromatographic method for determination of canrenone in serum
โœ Besenfelder, E. ;Endele, R. ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 215 KB ๐Ÿ‘ 1 views

Spironolactone (I), a potassium sparing diuretic, is widely used in the treatment of edema. Metabolic degradation starts with rapid deacetylation, leading to the short lived a-thiol [l]. Subsequent elimination of hydrogen sulfide yields canrenone (II), which exists in enzymatic equilibrium with canr