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Pd(0) catalyzed asymmetric amination of a prochiral bicyclic allylic diacetate

✍ Scribed by Gunter Muchow; Jean Michel Brunel; Michel Maffei; Olivier Pardigon; Gérard Buono


Book ID
108379036
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
644 KB
Volume
54
Category
Article
ISSN
0040-4020

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The palladium(0)-catalyzed alkylation of 2,3-bis(acetoxymethyl)bicyclo[2.2.1]hepta-2,5-diene 1 with malonate-type enolates as nucleophiles is investigated. A monoalkylated product is formed first, and undergoes (depending on the nucleophile used) a second intramolecular reaction leading to [a]