PCR analysis of INT-2 oncogene amplification in squamous cell carcinoma of the head and neck
✍ Scribed by Juan P. Rodrigo; Luis A. Garcia; Pedro S. Lazo; Sofia Ramos; Carlos Suárez
- Book ID
- 117402003
- Publisher
- SAGE Publications
- Year
- 1996
- Tongue
- English
- Weight
- 110 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0194-5998
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The presence of gene amplification was determined in 66 fresh head-and-neck SCC specimens using a battery of 9 different probes. Amplification of at least one gene was found in I 2 samples (18%), of which 7 were amplified at multiple loci (58%). We observed amplifications for EGFR (10% of samples) a
## Background. Abnormalities in chromosome llq13 regions have been frequently found in head and neck squamous carcinoma. Recent studies indicate that the PRAD-1 (also CCNDI), which encodes cyclin D1, is a putative oncogene that is an important component of this region. Methods. DNA was extracted