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PAX5 deletion is common and concurrently occurs with CDKN2A deletion in B-lineage acute lymphoblastic leukemia

✍ Scribed by Miyoung Kim; Jung Eun Choi; Cha Ja She; Sang Mee Hwang; Hee Young Shin; Hyo Seop Ahn; Sung-Soo Yoon; Byoung Kook Kim; Myoung Hee Park; Dong Soon Lee

Book ID
116304880
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
211 KB
Volume
47
Category
Article
ISSN
1079-9796

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Deletion of the 9p21 chromosomal region is frequently found in childhood acute lymphoblastic leukemia (ALL). The target of these deletions is CDKN2A, a gene encoding both p16(INK4a) and p14(ARF). However, contiguous genes such as CDKN2B, encoding p15(INK4b), or MTAP, encoding methylthioadenosine pho