CDKN2A, CDKN2B, and MTAP gene dosage per
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RaphaΓ«lle Bertin; CΓ©cile Acquaviva; Delphine Mirebeau; Christine Guidal-Giroux;
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Article
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2003
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John Wiley and Sons
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English
β 361 KB
Deletion of the 9p21 chromosomal region is frequently found in childhood acute lymphoblastic leukemia (ALL). The target of these deletions is CDKN2A, a gene encoding both p16(INK4a) and p14(ARF). However, contiguous genes such as CDKN2B, encoding p15(INK4b), or MTAP, encoding methylthioadenosine pho