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Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study

✍ Scribed by Miyoung Kim; Seon-Hee Yim; Nam-Sun Cho; Seong-Ho Kang; Dae-Hyun Ko; Bora Oh; Tae Young Kim; Hyun Jung Min; Cha Ja She; Hyoung Jin Kang; Hee Yung Shin; Hyo-Sup Ahn; Sung Soo Yoon; Byoung Kook Kim; Hai-Rim Shin; Kyu Sup Han; Han Ik Cho; Dong Soon Lee


Book ID
113513600
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
357 KB
Volume
195
Category
Article
ISSN
0165-4608

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Deletion of the 9p21 chromosomal region is frequently found in childhood acute lymphoblastic leukemia (ALL). The target of these deletions is CDKN2A, a gene encoding both p16(INK4a) and p14(ARF). However, contiguous genes such as CDKN2B, encoding p15(INK4b), or MTAP, encoding methylthioadenosine pho