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Hyperdiploidy with trisomy 9 and deletion of the CDKN2A locus in T-cell acute lymphoblastic leukemia

✍ Scribed by Kelley Healey; S. Lauren Gray; Gregory E. Halligan; Ann S. McKenzie; Jean-Pierre de Chadarévian; Jennifer J.D. Morrissette


Book ID
113513493
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
206 KB
Volume
190
Category
Article
ISSN
0165-4608

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CDKN2A, CDKN2B, and MTAP gene dosage per
✍ Raphaëlle Bertin; Cécile Acquaviva; Delphine Mirebeau; Christine Guidal-Giroux; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 361 KB

Deletion of the 9p21 chromosomal region is frequently found in childhood acute lymphoblastic leukemia (ALL). The target of these deletions is CDKN2A, a gene encoding both p16(INK4a) and p14(ARF). However, contiguous genes such as CDKN2B, encoding p15(INK4b), or MTAP, encoding methylthioadenosine pho