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Pattern of expression of cyclin D1/CDK4 complex in human placenta during gestation

✍ Scribed by M. De Falco; V. Fedele; L. Cobellis; A. Mastrogiacomo; D. Giraldi; S. Leone; L. De Luca; V. Laforgia; A. De Luca


Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
540 KB
Volume
317
Category
Article
ISSN
0302-766X

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We analyzed the expression and amplification of cyclin D1 and CDK4 genes in ovarian carcinomas. Northern blot analysis revealed overexpression of cyclin D1 in 12 of 65 (18%) ovarian carcinomas while CDK4 was overexpressed in 7 of 48 cases (14%). None of the tumors showed amplification of any of the