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Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression

✍ Scribed by Mary Grillo; Matthew J. Bott; Neha Khandke; John P. McGinnis; Miriam Miranda; Muthupalaniappan Meyyappan; Edward C. Rosfjord; Sridhar K. Rabindran

Publisher
Springer US
Year
2005
Tongue
English
Weight
401 KB
Volume
95
Category
Article
ISSN
0167-6806

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Overexpression of cdk4/cyclin D1, a poss
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## Abstract The relation between expression of cell cycle–regulator molecules and apoptosis was examined in surgical specimens and cultured human lung carcinoma cell lines. Immunohistochemical analysis for 133 cases revealed 2 types of staining pattern. The first group consisted of 95 cases (71.4%)